THERAPEUTIC ALTERNATIVES: OTC meds; cheaper meds in same class
MEDICATION REVIEW: regularly review med list; remove unnecessary meds
DISCOUNT DRUGS: $4 drugs (Walmart, Target, etc); discount cards
SPLITTING PILLS: prescribe higher dose and advise patients to split pills
This section will explore each part of this acronym in detail. Explore the parts of GOT MeDS by selecting the drop-down arrow next to each title. Questions at the end will ask you to apply the information within these parts.
The most obvious and important tactic is to always use generics when available. Generic medicines are essentially copies of brand-name medications and are monitored by the FDA to ensure they are equally as effective and safe as their brand-name counterparts. They contain the same active ingredient as the brand-name medicine, and they are subject to the same government rules about strength, quality, and purity.
Using generic medications can save patients a tremendous amount of money. According to UpToDate, an average 30-day supply of a “brand-name” prescription medicine costs about $250 a month without insurance coverage, whereas the average generic drug costs about $25 a month without insurance. In fact, as we discuss below, many generic drugs cost only $4 per month from a number of drug stores.
When prescribing a medication, you should always check to see if there is a:
Patients may be able to save money by ordering medications in bulk. For example, ordering a 3-month supply of medications can cost less (for example, discount medications are often $4 for a month supply and $10 for a 90-day supply) and require fewer co-pays over the course of a year for the patient.
One study found a 29% decrease in out-of-pocket costs with using 3-month vs 1-month supply.
OVER-THE-COUNTER (OTC) MEDICATIONS
Some medications are available at a lower cost without a prescription (over-the-counter (OTC) medications).
OTC medications are approved by the FDA and are guaranteed to be safe and effective.
For example, medications for reflux/heartburn like Nexium or Prilosec are available as lower-cost non-prescription versions. Ibuprofen can be obtained without a prescription at much lower cost, and often times can be even cheaper when purchased in bulk. For example, Costco Wholesale sells a pack of 1000 200mg Ibuprofen caplets for $8.79, or about 1 cent a caplet. The same medication in a brand name 50 caplet bottle sells for $6.99, or 14 cents a caplet, a 93% markup from the bulk price for the same medication. Even for the same volume of caplets, a non-brand name can save money. A 50 caplet bottle of drug-store-brand 200mg Ibuprofen sells for $5.49, or 11 cents a caplet, still 21% lower cost per tablet than the brand name.
LESS EXPENSIVE BRAND-NAME MEDICATIONS
For many conditions, there are multiple medication options available. Drug coverage plans are often “tiered,” meaning that different medications will cost patients different out-of-pocket amounts depending on which tier that medication is in.
Although it may be challenging for prescribers to always know which are the “preferred drugs” for a given insurance plan, it is important that they, at the very least, alert patients that there could be alternatives available so they should check with their insurance and the medication can be changed to a different drug that will be equally effective. Better yet, physicians can work with clinical pharmacists who can help ensure that new prescriptions are personalized to be the best option for a given patient. Many electronic medical records are now building in tools that provide alerts about which medications are on the formulary or are preferred by the patient’s insurance plan.
Of course, the most effective way to decrease cost, pill burden and medication regimen complexity simultaneously is to stop medications that patients do not need.
Sometimes medications are started for a specific indication, such as PPI medication for a gastric ulcer, and are never discontinued even after the problem has resolved. Or, even worse, we have seen patients who were started on a PPI as prophylaxis while intubated in an ICU, and then the med was simply added to their list. Years later, they were still taking a PPI though nobody really knew why anymore.
As patients’ overall conditions change, sometimes certain medications are no longer helpful, such as a statin for primary prevention in a patient who has terminal cancer.
By regularly reviewing medications and practicing the principles of “conservative prescribing,” clinicians can make a big difference for patients.
“Deprescribing” describes the process of intentionally tapering, stopping, discontinuing, or withdrawing medications, with the goal of improving outcomes by improving a person’s health and/or reducing the risk of adverse side effects.
There are a number of resources to assist with identifying medications that may be inappropriate for use in the elderly, including the Beers Criteria and the STOPP criteria.
Proton pump inhibitors for uncomplicated peptic ulcer disease at full therapeutic dosage for >8 wk
128
Aspirin with no history of coronary, cerebral. or peripheral vascular symptoms or occlusive arterial events
66
Benzodiazepines in patients who have had >1 fall in the past 3 mo
56
Duplicate drug class prescriptions
56
Long-term (>1 mo), long-acting benzodiazepines or benzodiazepines with long-acting metabolites
48
Long-term use of nonsteroidal anti-inflammatory drug (>3 mo) for relief of mild joint pain in osteoarthritis
19
Long-term opiates in those with recurrent falls (>1 fall in past 3 mo)
18
Neuroleptic drugs in those with recurrent falls (>1 fall in past 3 mo)
16
Long-term opiates in those with recurrent falls (>1 fall in past 3 mo)
14
Abbreviation: STOPP, Screening Toll of Older Person’s potentially inappropriate Precriptions.
a A total of 610 STOPP criteria PIMs were prescribed to the 600 patients studied.
b The number of PIM instances.
Many large chain stores (eg, Costco, Target, WalMart, Kmart, Sam’s Club, HEB) have a number of generic medications for $4 per month or $10 per three-months. Even if the patient has private insurance, it may be even less expensive for him or her to use a $4 plan rather than paying a co-pay at a different pharmacy.
A number of $4 drug lists are available at www.4dollardrugs.com. Clinicians should be aware of local options and can print out the list to have handy to refer to with patients. We have heard about many resident physicians and primary care physicians who have posted the list in their office next to the desk or have hand-out copies available to regularly refer to when writing a new prescription for a patient.
Patients should also be aware that there can be big differences in prices charged for the same exact medication depending on which drugstore is used. Patients should compare prices between local pharmacy options. There are a growing number of online resources and mobile apps to help patients identify the best prices locally, such as GoodRx.com which compares local prices and also provides discount coupons for many medications.
Sometimes higher dose tablets, which can cost the same as a lower dosage, can be split. This could effectively save up to 50% each month for patients.
For example, if a patient takes a 20mg dose of a certain drug, the 40mg version of the same drug may cost the exact same amount, so the 40mg pills can be prescribed and the patient can split the pill each day.
CAUTION: NOT ALL PILLS CAN BE SPLIT.
IMPORTANT TO CONSULT WITH A DOCTOR.
As per GoodRx.com, here are some important things to consider before pill splitting:
Pill splitters can be bought at most pharmacies for around $5.
Some immediate-release tablets may be split, and tablets that are scored have been evaluated by the FDA for safety.
Not all pills can be split.
DON’T SPLIT DRUGS WITH:
an enteric coating
(designed to protect the stomach)
drugs that are time-release or long-acting
drugs taken more often than once a day
drugs in capsules
prepackaged drugs in specific doses
(like birth control pills)
Pill splitting is also not recommended for situations where the patient might not understand the concept or be capable of splitting a pill. Pill splitting often requires fine tactile skills, and is not for everyone.
Recommend to patients that they use a pill box and ensure both halves of the same pill are taken within a 48-hour period. This will minimize variation that comes from uneven pill splitting.
For a complete list of pills that should not be crushed, see the Institute for Safe Medication Practices list.
Amlodipine (Norvasc)
Atenolol (Tenormin)
Atorvastatin (Lipitor)
Citalopram (Celexa)
Clonazepam (Klonopin)
Doxazosin (Cardura)
Finasteride (Proscar)
Levothyroxine (Synthroid)
Lisinopril (Zestril)
Lovastatin (Mevacor)
Metformin (Glucophage)
Metoprolol (Toprol)
Nefazodone (Serzone)
Olanzapine (Zyprexa)
Paroxetine (Paxil)
Pravastatin (Pravachol)
Quinapril (Accupril)
Rosuvastatin (Crestor)
Sertraline (Zoloft)
Sildenafil (Viagra)
Simvastatin (Zocor)
Tadafil (Cialis)
Vardenafil (Levitra)
From Consumer Reports Best Buy Drugs
While there are many things we as individual prescribers can do on our own to improve our prescribing habits for patients, we also must recognize the structural supports that will help ingrain this work. We should be aware of the resources available to us and also can advocate for those that will help achieve these strategies.
For example:
Electronic health records that have the built-in ability to make specific recommendations based on the patient’s insurance and formulary
Clinical pharmacists that are embedded within clinics and clinical team
Costs of Care module:
“GOT MeDS: Having Value Conversations With Patients About Medication Costs”
(10-minute video module, with free CME credit)
“Patient education: Coping with high drug prices (Beyond the Basics) ”
from UpToDate
(free)
Kumar, Rupali et al. GOTMeDS?: Development and Evaluation of an Interactive Module for Trainees on Reducing Patient’s Drug Costs. The American Journal of Medicine, Volume 129, Issue 12, 1338 – 1342
ARTICLE
This article discusses the dangerous state of overprescribing and the need to deprescribe in a supervised and methodical manner, as well as the need for more research in this area.
APP
iMedical Apps: Medstopper (desprescribing tool) review.
The MedStopper app includes other deprescribing resources such as Beers and STOPP criteria as well as the validated Edmonton Frail Scale and is described in this review as recommended for any healthcare provider who cares for geriatric patients or patients of any age on too many medications including students, NP’s, PA’s, geriatricians and other primary care providers.
ARTICLE
A large proportion of Americans are enrolled in 3-tier pharmacy benefit plans. We studied whether patients enrolled in such plans who receive generic or preferred brand-name agents when initiating chronic therapy were more adherent to treatment than those who received nonpreferred brand-name medications.
ARTICLE
Interview with Dr. Michael White, Department of Pharmacy Practice at the University of Connecticut on the difference between generics and brand names and whether one is really preferable to the other.